After the death of her closest two friends, young Daphne Lessing suffers a loss of faith, then a lapse in memory. Confronted with a diagnosis of schizophrenia and a pregnancy she neither planned nor is able to explain, Daphne is forced into a terrible choice: lose her child or lose her mind. "The Substance of Things Hoped For" traces Daphne's desperate search for the past she cannot recall, the father she never had, and the child she may never know.